UNITED STATES, WASHINGTON (OBSERVATORY) — In diabetes, it is highly advisable to reduce weight. If weight loss for one reason or another is difficult, patients may be advised to bariatric surgery. However, in practice, bariatria is rarely offered. Most likely due to prejudice against invasive interventions.
“Gastric bypass surgery is a highly effective treatment for obesity and type 2 diabetes . However, very few suitable patients – about 1% – are offered surgery, many prefer less invasive approaches, ”commented Professor Gertrude Mingroun of King’s College in London.
Gertrude Mingroun led the development of a new device with the effect of bariatric surgery, but an order of magnitude less invasive. As part of the project, specialists created a duodenal insert – a fluoropolymer sleeve (Sleeveballoon), penetrating 60–80 cm into the small intestine.
A sleeve-like device consists of an intragastric balloon with a central channel that allows food to pass into the proximal small intestine, which is lined with a sleeve extending into the duodenum and then into the jejunum. The device reduces the volume of the stomach by about 2/3.
The sleeve is inserted into the stomach and intestines during minimally invasive surgery under general anesthesia. After a while (presumably 6-12 months), it can be easily removed.
A study published in the journal EBioMedicine showed that the new device shows impressive results in the treatment of general obesity / liver obesity and diabetic control.
Researchers compared the effects of Sleeveballoon and traditional gastric bypass surgery on 30 rodents fed the same high-fat diet.
It was found that the metabolic effects of the Sleeveballoon device are similar to those of gastric bypass, but have clear advantages over the traditional method:
- firstly, insulin sensitivity, and heart function improved more significantly;
- secondly, the gastric shunt has a drawback: it often causes gyoglycemic conditions associated with the movement of the contents of the stomach into the intestine without proper digestion. And Sleeveballoon provides only a slowdown in digestion, which, on the contrary, stabilizes the level of sugar in the blood.
After six months of using the new device, food consumption in experimental mice with diabetes decreased by 60% and fat mass decreased by 57%. The impact on diabetes was just as impressive: blood glucose decreased by 65%. Ectopic fat deposition has decreased dramatically, and glycogen content has increased in both the liver and skeletal muscle.
Researchers expressed satisfaction with the results, and Gertrude Milgroone commented: “Currently, 500 million people suffer from type 2 diabetes, and about two billion suffer from liver obesity. We hope that our discovery will soon be tested in public, and will revolutionize the way we fight the diabetes epidemic.”
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