Biologists have stopped the most dangerous breast cancer

UNITED STATES (OBSERVATORY NEWS) — Scientists have learned to deal with the spread of one of the most dangerous types of breast cancer, against which traditional therapy is powerless.

Doctors have determined which protein synthesis in the cancer cell needs to be suppressed so that the tumor does not give metastases .

The achievement is described in a scientific article published in the journal Oncogene team led by Paul Shore from the University of Manchester.

About 15% of all cases of breast cancer are the so-called triple-negative breast cancer . It is called so because tumor cells do not produce any of the three proteins that serve as targets for hormone therapy. It is easy to guess that this makes the disease invulnerable to a powerful treatment method. Yes, and to other types of therapy, this ailment is quite stable.

In addition, this type of disease is aggressive: it is more likely to give metastases, and tumors appear again after treatment more often than in the case of other types of breast cancer.

As a result, in the UK alone, this insidious disease is diagnosed annually in eight thousand women.

Now scientists have figured out which tumor proteins can target new drugs. It is about two connections: RUNX2 and CBF.

To detect them, biologists edited the DNA of cancer cells using the CRISPR procedure . Removing the genes responsible for the synthesis of a protein, they actually stopped its production. The tests were carried out “in vitro” on cell cultures.

It turned out that suppressing the synthesis of RUNX2 or CBF prevents tumors from metastasizing to adjacent bone tissue. The absence of CBF is a particularly severe blow to tumor development.

Meanwhile, when the researchers “manually” returned the protein to the tumor, its distribution resumed.

It turns out that if scientists create a drug that suppresses the synthesis of any of these proteins, it can be used to combat the spread of triple negative breast cancer. However, it should be noted that these same proteins are also present in healthy cells.

Therefore, the medicine is required in some way to target only cancerous ones.

It is also important to note that this type of cancer in turn is divided into several subtypes. Now researchers are going to test their findings on at least a few of them.

“This discovery is an important milestone in understanding how metastatic cancer spreads. But, of course, it has a long way to go before it turns into effective treatment methods,” Shor summarizes.


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