UNITED STATES (OBSERVATORY NEWS) — Russian doctors have created a new technique for correcting the negative manifestations of menopause in women. First of all, this concerns the prevention and correction of psychoemotional disorders. Scientists have conducted animal studies that have shown that combining hormone therapy with individually selected doses of vitamin D3 significantly reduces depression and anxiety, as well as other negative manifestations of menopause, but this requires individually selected high doses. Also, according to the indications, such therapy was carried out for a number of women with especially serious problems: it turned out that the new combination therapy can extend the period of fertility.
Climax is a long period in a woman’s life associated with the gradual cessation of estrogen production by the ovaries and the completion of reproductive function. Its onset occurs after the age of 50 years. Pathological manifestations of menopause negatively affect the professional activities of women, their social activity and interpersonal relationships, which affects the quality of life. In many menopause occurs with a whole complex of vegetative-vascular, mental and metabolic-endocrine disorders. Such problems are observed in 30-60% of women.
Scientists of the Institute of Physiology named after I.P. Pavlov of the Russian Academy of Sciences, with the support of the Russian Science Foundation, are developing a new technique for correcting the negative manifestations of menopause. First of all, this concerns the prevention and correction of psychoemotional disorders. As Izvestia was explained by a leading researcher in the Laboratory of Neuroendocrinology of the Institute of Physiology named after I.P. Pavlov Yuli Fedotov, during the studies, scientists established a relationship between low levels of vitamin D3 (cholecalciferol) in the body and a predisposition to the appearance and development of affective disorders in women during menopause.
– Studies have shown that the level of vitamin D3 in women can be one of the prognostic factors for the development of anxiety-depressive disorders during the initial stage of menopause. Moreover, the prevention of a deficiency of this substance can play a leading role in preventing the development of psychopathologies,” the specialist explained.
From 2016 to 2018, scientists performed two parts of the study: preclinical (in animals) and clinical – in volunteers. Now the work is ongoing.
Matter in the dose
Previously, all doses and treatment methods were tested in rats . The experiment involved females of different ages: young (2.5-3 months), middle age (12-14 months) and old (16-18 months). An experimental model of menopause was recreated on them: the ovaries were removed from the animals, after which they waited three months until the hormone level approximately corresponded to that during menopause in women. Further, all three groups of rats of different ages were injected with vitamin D3 in three different doses: low, medium and high. Vitamin A was administered alone or in combination with a low dose of the hormone estradiol (similar to hormone therapy in women).
In some cases, a strong antidepressant effect was achieved, and in some it did not work at all. That is, it turned out that therapy with vitamin D3 is effective only in the case of an individual approach, taking into account age and hormonal status.
Then, scientists conducted clinical trials on women of different ages, including those whose menopause started prematurely (33 years). Clinical studies have confirmed the effectiveness of the combined use of hormone therapy in combination with vitamin D3 in different doses, depending on the age of the patients.
“ In parallel, we found that the appointment of vitamin D3 helps restore hormonal levels in young women with premature menopause, thereby increasing the likelihood of conception of a child in conditions of exhausted ovaries ,” said Julia Fedotova. – This can be used in preparation for in vitro fertilization.
Reception under control
Scientists have prescribed an algorithm for selecting doses of drugs and treatment tactics for various age groups. The authors of the work emphasize that the main thing in such therapy is compliance with the dosages depending on the age of the woman and her hormonal background.
Maria Vedunova, director of the Institute of Biology and Biomedicine at Lobachevsky University, told Izvestia that the role of vitamin D in the functioning of the body, especially the female, in both reproductive and age-related aspects is extremely difficult to overestimate.
– Vitamin D is a necessary participant in the synthesis of female hormones, especially estrogen. For a long time in clinical practice, there have been approaches that actively use vitamin D to correct hormonal and age-related changes in the female body. This therapy has not always been effective, most likely this was due to the complexity of controlling the absorption of the vitamin, she said.
Director of the Higher Medical and Biological School of SUSU (university participating in the project “5-100”) Vadim Tseilikman is sure that the proposed therapy can be effective.
– Undoubtedly, research by Professor Fedotova deserves attention and support. Currently, the attention of researchers in various countries is attracted to vitamin D as a promising antidepressant . Its biological effect is not limited to bone tissue, ”he said. – Many internal organs have receptors for the vitamin and its biological effect is similar to the action of hormones. These properties served as the basis for studies of its effect on behavioral activity.
Earlier, scientists from the United States conducted a large study in which they showed that a daily intake of 400 IU of vitamin D (as recommended by the U.S. Institute of Medicine) in combination with 1 mg of calcium does not reduce the risk of depression. At the same time, the authors note: in order to determine whether a vitamin can be useful in prevention and treatment among specific population groups, additional studies using higher doses are required. This was done by Russian scientists, who confirmed that much higher dosages are required for women during menopause. However, you need to use the vitamin under the supervision of the attending physician, and, in case of normalization of its level, you should take a break between courses to avoid overdose.
This article is written and prepared by our foreign editors writing for OBSERVATORY NEWS from different countries around the world – material edited and published by OBSERVATORY staff in our newsroom.
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