New diabetes drugs lower risk of heart failure and death

UNITED STATES, WASHINGTON (OBSERVATORY) — A new class of antidiabetic drugs – sodium glucose cotransporter inhibitors reduce blood glucose concentration due to a decrease in glucose reabsorption in the proximal renal tubules independent of insulin, that is, by stimulating its excretion in the urine.

In addition to the benefits of SGLT2 inhibitors identified in previous clinical trials, researchers at the Karolinska Institute report that these diabetes drugs reduced their risk of heart failure by 34% and premature death by 20%.

These findings are based on a study of data from approximately 21 thousand patients with type 2 diabetes who were treated with two SGLT2 inhibitors from April 2013 to December 2016. Experts compared the effects of treatment with SGLT2 inhibitors and DPP4 inhibitors in favor of the former.

Scientists acknowledge that their results mainly relate to dapagliflozin, the type of SGLT2 inhibitor most common in Scandinavia during the study period. However, another SGLT2 inhibitor, canagliflozin, marketed under the brand name Invokana, also protects the kidneys and heart and reduces the risk of death.


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