Researchers reveal new way to slow brain aging

UNITED STATES (OBSERVATORY NEWS) — Activating a certain type of immune cell that accumulates in an aging brain can reduce cognitive decline. This is the conclusion drawn by American researchers who claim that their study may offer new ways to combat the neurodegenerative disorders associated with aging.

Researchers at the Albany College of Medicine in the United States have discovered a certain type of immune cell that accumulates in aging brains. Their activation can reduce the cognitive decline associated with aging, say study results published February 5 in the Journal of Experimental Medicine.

Innate lymphoid group 2 cells (ILC2) can help doctors fight brain aging. These cells are located in certain tissues of the body and participate in the regeneration processes, however, according to scientists, the prevalence of ILC2 cells in the central nervous system and their reaction to aging have not been known until now.

During their work, the study authors examined the brains of young and old mice and found that ILC2 accumulates with age in the choroid plexus, which produces cerebrospinal fluid. It is located next to the hippocampus, which plays a key role in cognitive processes.

A molecule to rejuvenate the brain

The researchers found that in old mice, the amount of ILC2 in the choroid plexus was three to five times higher than in young mice. A large number of ILC2 cells have also been found in this area of ​​the brain in the elderly.

In older mice, the ILC2 cells were functionally at rest, however, the researchers were able to activate them using Interleukin-33 (IL-33) molecules after which the cells began to produce proteins that stimulate the formation of neurons and extend their lives. Subsequently, the results of a number of cognitive tests in some old rodents have improved.


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