UNITED STATES (OBSERVATORY) – Scientists of the Institute of Biomedical Research in Barcelona have discovered a new protective mechanism of tumors in the human body. The study is published in Cancer Cell.
Experiments on patients with one of the cancer subtypes – three times negative breast cancer – rodents have shown that malignant cells are capable of endlessly dividing because of the activity of the p38alpha protein, which restores their DNA.
Scientists blocked the activity of the protein with specific inhibitors, coupled with classical drugs based on taxane, used in chemotherapy, paclitaxel and docetaxel.
As a result, the DNA of malignant cells appeared damaged, many of them died, and the tumor itself decreased.
Breast cancer is one of the most common oncological diseases (the second most often after lung cancer). Annually in the world about 500 thousand people die from it.
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There are three types of tumors: ER-positive, HER2-positive and three times negative cancer.
Previously, a group of researchers from Boston University discovered a protein responsible for the development of aggressive T-cell leukemia.